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Y-27632 | ROCK inhibitor

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Price:
$109.00
Catalog #:
C9127-2s
Quantity:
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Product Description

Y-27632 is widely used as a specific inhibitor of the Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family. It has been found to prevent dissociation-induced apoptosis in human embryonic stem cells and enhance the survival and cloning efficiency of dissociated hES cells without affecting their self-renewal properties or pluripotency. Y-27632 can also enhance survival during the transplantation of ES cell-derived neural precursors.

Technical information:

Chemical Formula:   C14H21N3O·2HCl
CAS #:   146986-50-7
Molecular Weight:   329.27
Purity:   >98%
Appearance:   White solid
Chemical Name:   (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Ishizaki, T. et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol (2000) 57: 976-983.
2. Koyanagi et al. Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J. Neurosci Res (2008) 86: 270-280.
3. Watanabe et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech (2007) 25: 681-686.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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