Loading... Please wait...

Categories

Our Newsletter


Sitagliptin | DPP-IV/DPP-4 inhibitor

Sitagliptin.jpg
  • Sitagliptin.jpg
  • Sitagliptin, 400x400px, png
Price:
$89.00
Catalog #:
C7482-5
Quantity:
Buy in bulk and save

For larger amounts,
please Email us for a quote.

Product Description

Sitagliptin (also named MK-0431 and marketed as Januvia) is a competitive inhibitor of the enzyme dipeptidyl peptidase 4 (DPP-4). Sitagliptin can increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.

Technical information:

Chemical Formula:   C16H15F6N5O
CAS #:   486460-32-6
Molecular Weight:   407.31
Purity:   >98%
Appearance:   White solid
Chemical Name:   (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Herman GA, et al.Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther 2005; 78 (6): 675–88.
2. Herman GA, et al. Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects. J Clin Pharmacol 2006;46 (8): 876–86.
3. Lee B, et al. Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys. Eur J Pharmacol. 2008;589(1-3):306-14

Other Information:

Product Specification (pdf)
MSDS (pdf)

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Sitagliptin | DPP-IV/DPP-4 inhibitor to your wish list.

You Recently Viewed...