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Rapamycin | mTOR inhibitor

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Price:
$129.00
Catalog #:
C7272-5
Quantity:
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Product Description

Rapamycin binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex1 (mTORC1). Rapamycin has variety of usages in vitro and in vivo. It is an immunosuppressant drug used to prevent rejection in organ transplantation. It showed lifespan extension in mice. Its antiproliferative effects led to treat tuberous sclerosis complex and several cancers.

Technical information:

Chemical Formula:   C51H79NO13
CAS #:   53123-88-9
Molecular Weight:   914.17
Purity:   >98%
Appearance:   White solid
Chemical Name:   (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]-oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Vézina C et al. Rapamycin (AY-22,989), a new antifungal antibiotic. J. Antibiot. 1975; 28 (10): 721.
2. Price, D.J., et al. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science. 1992; 257: 973-977.
3. Heitman, J., et al. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991; 253: 905-909.
4. Wells, A.D. et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat. Med.1999; 5: 1303-1307
5. Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460 (7253): 392–5.
6. Wendel HG, et al. "Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy". Nature 2004;428 (6980): 332–7
7. Ehninger D. et al. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat. Med. 2008;14 (8): 843–8

Other Information:

Product Specification (pdf)
MSDS (pdf)

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