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- Latanoprost | Prostaglandin F receptor (FP) agonist
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- Latanoprost | Prostaglandin F receptor (FP) agonist
Product Description
Latanoprost is a potent and selective agonist of Prostaglandin F receptor (FP). It activates FP, a G-protein coupled receptor (GPCR), with EC50 of 10 nM, and with at least 500-fold selectivty over other Prostaglandin receptors. (1) Upon activation, FP promotes the decrease of intraocular pressure and contraction of smooth muscle.
Clinically, Latanoprost (aka Xalatan(r)) is used as a topical ophthalmic solution for controlling the progression of glaucoma or ocular hypertension by increasing the outflow of aqueous fluid from the eyes, therefore reducing intraocular pressure. (2)
Technical information:
| Chemical Formula: | C26H40O5 | |
| CAS #: | 130209-82-4 | |
| Molecular Weight: | 432.59 | |
| Purity: | > 98% | |
| Appearance: | clear oil | |
| Chemical Name: | (Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate | |
| Solubility: | Up to 100 mM in DMSO | |
| Synonyms: | latanoprost, Xalatan® |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Stjernschantz et al., From PGF2?-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. Invest.Ophthalmol.Vis.Sci. 2001, 42(6):1134-45. Pubmed ID: 11328719 |
| 2. | Camras CB et al., Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost Study Groups. Ophthalmology. 1996, 103(11):1916-24. Pubmed ID: 8942890 |
Other Information:
Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.
