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- Hh-Ag1.5 | Hedgehog pathway activator
Product Description
Hh-Ag1.5 is a small-molecule chemical agonist of Smoothened (Smo) receptor and is an activator of sonic hedgehog (Shh) signaling. It is derived from an initial synthetic hit compound "Hh-Ag1.1", and optimized to achieve the activity IC50 = 1 nM for agonist activity.
Technical information:
| Chemical Formula: | C28H26N3OS | |
| CAS #: | 612542-14-0 | |
| Molecular Weight: | 526.04 | |
| Purity: | >98% | |
| Appearance: | Yellow solid | |
| Chemical Name: | 3-chloro-4,7-difluoro-N-(4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide | |
| Solubility: | Up to 50 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery. Borzillo and Lippa. Current Topics in Medicinal Chemistry 2005, (5), 147-157. |
| 2. | Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. Frank-Kamenetsky et. al. Journal of Biology 2002 (1): 10.2-10.19. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
