CP-690550 (Tofacitinib) | JAK1/2/3 inhibitor

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CP-690550 (Tofacitinib) | JAK1/2/3 inhibitor

Price:

$79.00

Catalog #:

C2716-2s

* Package Size:

2 mg (10 mM solution in DMSO)
2 mg (powder)
10 mg (powder)
50 mg (powder)

Quantity:

Buy in bulk and save

For larger amounts,
please Email us for a quote.

Product Description

CP-690,550 is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. In enzyme assays it potently inhibited recombinant human kinase protein JAK1 (IC50=3.2nM), JAK2 (IC50=4.1nM) and JAK3 (IC50=1.6nM), but in cellular assays it potently inhibited signaling through JAK1 and JAK3 with 5-100 fold selectivity over JAK2.

Technical information:

Chemical Formula:		C₁₆H₂₀N₆O
CAS #:		477600-75-2
Molecular Weight:		312.38
Purity:		>98%
Appearance:		White solid
Chemical Name:		3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile
Solubility:		Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

1.	Meyer DM, et al. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J Inflamm (Lond). 2010 11;7:41.
2.	Flanagan ME, et al. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J Med Chem. 2010 53(24):8468-84

Other Information:

Product Specification (pdf)
MSDS (pdf)