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CP-690550 (Tofacitinib) | JAK1/2/3 inhibitor

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Price:
$79.00
Catalog #:
C2716-2s
Quantity:
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Product Description

CP-690,550 is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. In enzyme assays it potently inhibited recombinant human kinase protein JAK1 (IC50=3.2nM), JAK2 (IC50=4.1nM) and JAK3 (IC50=1.6nM), but in cellular assays it potently inhibited signaling through JAK1 and JAK3 with 5-100 fold selectivity over JAK2.

Technical information:

Chemical Formula:   C16H20N6O
CAS #:   477600-75-2
Molecular Weight:   312.38
Purity:   >98%
Appearance:   White solid
Chemical Name:   3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)
piperidin-1-yl)-3-oxopropanenitrile
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Meyer DM, et al. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J Inflamm (Lond). 2010 11;7:41.
2. Flanagan ME, et al. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J Med Chem. 2010 53(24):8468-84

Other Information:

Product Specification (pdf)
MSDS (pdf)

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