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BIBR-1048 (Dabigatran etexilate) | Thrombin inhibitor

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Price:
$169.00
Catalog #:
C2104-5
Quantity:
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Product Description

BIBR-1048 (Dabigatran etexilate) is an orally-active, non-covalent, reversible inhibitor of thrombin. It is the double ester prodrug of BIBR-953, which has an IC50 against thrombin and trypsin at 9.3, and 50.3 nM, respectively. (1) In addition to inhibiting free thrombin, BIBR-1048 also inhibits thrombin generation, fibrin-bound thrombin, and thrombin-induced platelet aggregation. (2)

Technical information:

Chemical Formula:   C34H41N7O5
CAS #:   211915-06-9
Molecular Weight:   627.73
Purity:   > 98%
Appearance:   white
Chemical Name:   (E)-ethyl 3-(2-((4-(N'-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
Solubility:   Up to 100 mM in DMSO
Synonyms:   BIBR 1048, BIBR1048, BIBR-1048, Dabigatran, Pradaxa

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Abbenante et al., Protease Inhibitors in the Clinic, Med. Chem. 2005, 1, 71-104. Pubmed ID: 16789888
2. Jackson, J.M., Drug Review - Dabigatran for stroke prevention in atrial fibrillation, Drugs in Context, 2011, 6, 11-28.

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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