ABT-737 | Apoptosis inhibitor - Cellagen Technology

Loading... Please wait...

New Products

Biologix SBS Format Cryogenic Vials-1mL, 2mL, 5mL, 48-Well, Racked, External Thread, 10 Sets/Pack, 2 Packs/Case

$253.89

Choose Options
Cryogenic Vials with Side Bardcode-2.0 ml External Thread

$67.49

Choose Options
Biologix Beakers-50/100/250/400/800/1000ml, Case of 100

$22.99

Choose Options
CryoKING Liquid Nitrogen Tank - Laboratory Series 31.5 L/35.5 L, Including 6 Square Racks(4 layers) with 5*5 Cryogenic Boxes

$856.49

Choose Options
CryoKING Liquid Nitrogen Tank Portable Dewar Series 2L/3L/6L/10L

$228.19

Choose Options

Our Newsletter

ABT-737 | Apoptosis inhibitor

Price:

$119.00

Catalog #:

C2281-5

* Package Size:

5 mg (10 mM solution in DMSO)
5 mg (powder)
25 mg (powder)
100 mg (powder)

Quantity:

Buy in bulk and save

For larger amounts,
please Email us for a quote.

Product Description

ABT-737 is a selective and potent small molecule inhibitor of protein Bcl-2, Bcl-XL, and Bcl-w. Like a BAD BH3 peptide, ABT-737 binds to and antagonizes anti-apototic Bcl-2 family proteins instead of directly activating the apoptotic process. ABT-737 binds with high affinity (ki < 1nm) to Bcl-XL, Bcl-2 and Bcl-w, but not to Bcl-B, Mcl-1 and Al protein.

ABT-737 displays a wide range of single-agent activity against cells from lymphoma, leukemia, solid tumor SCLC, and primary cells derived from patient. In animal models, ABT-737 causes tumor regression and improves survival^1-2. ABT-737 has shown synergistic anti-tumor activity when used together with vorinostat or bemicitabine^3,4.

Technical information:

Chemical Formula:		C₄₂H₄₅CIN₆O₅S₂
CAS #:		852808-04-9
Molecular Weight:		813.43
Purity:		>98%
Apperance:		Off white solid
Chemical Name:		4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino) -1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Solubility:		Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

1.	Oltersdorf, T. et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 2005 Jun 2;435(7042):677-81.
2.	Van Deelft , MF. et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006 Nov;10(5):389-99.
3.	Zhang, C. et al. Synergistic anti-tumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1. Mol Cancer Ther. 2011 Jul;10(7):1264-75.
4.	Wiegmans AP, et al. Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737. Cancer Res. 2011

Other Information:

Product Specification (pdf)
MSDS (pdf)