RO318959 (Saquinavir) | HIV-1 protease inhibitor

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RO318959 (Saquinavir) | HIV-1 protease inhibitor

Price:

$159.00

Catalog #:

C7318-2s

* Package Size:

2 mg (10 mM solution in DMSO)
2 mg (powder)
10 mg (powder)
50 mg (powder)

Quantity:

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For larger amounts,
please Email us for a quote.

Product Description

Saquinavir is a decahydroisoquinoline-based, selective inhibitor of aspartic protease encoded by HIV with an IC50 range of 0.5-6.0 nM and IC90 range of 6.0-30.0 nM. [1] Binding inhibition constants for saquinavir against HIV-1 and HIV-2 are 0.12 nM and
Antiviral potency of saquinavir were shown in JM cells infected with HIV-1 strain GB8 with a IC50 of 2.5 nM. [2] Similarly, and IC50 of 2 nM was obtained against HIV-1 (strain RF) in C8166 cells.

Saquinavir was shown to be a substrate for P-glycoprotein transporter protein, affecting intracellular concentrations and bioavailability. [3]

Technical information:

Chemical Formula:		C₃₈H₅₀N₆O₅
CAS #:		127779-20-8
Molecular Weight:		670.84
Purity:		>98%
Appearance:		White
Chemical Name:		(2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-decahydroisoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide
Solubility:		Up to 22 mM in DMSO
Synonyms:		RO318959, RO-31-8959, saguinavir, Fortovase, Invirase

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

1.	Craig et al., Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase. Anvitiral Res. 1991, 16, 295-395. Pubmed ID: 1810306
2.	Roberts et al., Rational design of peptide-based HIV proteinase inhibitors. Science, 1990, 248, 358-361. Pubmed ID: 2183354
3.	Kim et al., Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J. Pharmacol. Exp. Ther. 1998, 286(3), 1439-1445. Pubmed ID: 9732409

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.