Mocetinostat (MGCD0103) is a potent and isotype-selective inhibitor of histone deacetylases (HDACs). In cell-free assays, Mocetinostat (MGCD0103) exhibited most potent inhibition against human HDAC1 (IC50 = 0.15 ?M) and also has inhibitory activity against HDAC2, HDAC3, and HDAC11, with IC50 values ranged 0.3 to 1.7 ?M. No activity was showed on HDACs 4-8. [1] Mocetinostat (MGCD0103) exhibited potent inhibition activity in proliferation of human cancer cell lines, both in cell-based assay and in human tumor xenografts in nude mice. [1]
Mocetinostat (MGCD0103) has been evaluated in Phase II clinical trials in patients with metastatic leiomyosarcoma [2] and Hodgkin??s lymphoma [3]."

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20^oC desiccated.

Reference:

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.